Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.38 |
| ▸ | WNT3 | P56703 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BRD2 | P25440 | 2/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732376 | 0.89 | WNT3 (0.36) | DRD2ADRA1DADRA1AADRA1BWNT3 | |
| SCHEMBL4733825 | 0.86 | SFRP1 (0.46) | WNT3SFRP1BRD4BRD2BRD3 | |
| SCHEMBL4797961 | 0.85 | BRD4 (0.36) | DRD2ADRA1DADRA1AADRA1BWNT3 | |
| SCHEMBL4735151 | 0.82 | BRD4 (0.35) | WNT3SFRP1BRD4BRD2BRD3 | |
| SCHEMBL4735477 | 0.75 | DPP4 (0.36) | DRD2WNT3SFRP1HTR1AHTR7 | |
| SCHEMBL4730171 | 0.74 | SFRP1 (0.42) | WNT3SFRP1BRD4 | |
| SCHEMBL4730889 | 0.72 | SFRP1 (0.48) | WNT3SFRP1BRD4BRD2BRD3 | |
| SCHEMBL4733107 | 0.72 | SFRP1 (0.43) | WNT3SFRP1 | |
| SCHEMBL4737035 | 0.72 | BRD4 (0.43) | WNT3SFRP1BRD4BRD2BRD3 | |
| SCHEMBL4782344 | 0.70 | HTR1A (0.37) | DRD2ADRA1DADRA1AADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |