Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737132 | 0.84 | MAPK14 (0.44) | MAPK14CXCR2GAATSHRPDK1 | |
| SCHEMBL4737075 | 0.81 | MAPK14 (0.40) | MAPK14CXCR2PDK1HSP90AA1HSP90AB1 | |
| SCHEMBL4735426 | 0.80 | OPRM1 (0.43) | MAPK14CXCR2TSHRPDK1 | |
| SCHEMBL4737014 | 0.79 | HDAC2 (0.42) | MAPK14CXCR2TSHR | |
| SCHEMBL4738924 | 0.79 | OPRM1 (0.40) | MAPK14CXCR2TSHR | |
| SCHEMBL4738700 | 0.78 | MAPK14 (0.39) | MAPK14CXCR2TSHRPDK1HSP90AA1 | |
| SCHEMBL4737305 | 0.78 | DRD4 (0.45) | MAPK14CXCR2GAATSHRLMNA | |
| SCHEMBL4733795 | 0.78 | KDM4E (0.51) | MAPK14CXCR2TSHRHSP90AB1 | |
| SCHEMBL4738909 | 0.77 | TSHR (0.44) | MAPK14CXCR2GAATSHRLMNA | |
| SCHEMBL4735517 | 0.77 | MAPK14 (0.38) | MAPK14CXCR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |