Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4737130 | 0.82 | NOTUM (0.37) | CNR1NOTUM | |
| SCHEMBL4733561 | 0.78 | KMT2A (0.35) | GABRA2GABRB2 | |
| SCHEMBL4733870 | 0.78 | NOTUM (0.42) | NOTUM | |
| SCHEMBL4737896 | 0.76 | BRD4 (0.41) | GABRA2GABRB2NOTUM | |
| SCHEMBL19284340 | 0.68 | GABRA2 (0.46) | GABRA2GABRB2 | |
| Hydrochloric Acid SCHEMBL23389304 | 0.65 | CYP11B2 (0.35) | — | |
| SCHEMBL14786484 | 0.65 | CYP11B2 (0.35) | — | |
| SCHEMBL28224364 | 0.65 | ALPL (0.41) | — | |
| SCHEMBL4734971 | 0.62 | PTGER1 (0.43) | GABRA2GABRB2 | |
| SCHEMBL23389306 | 0.62 | ALDH1A1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |