Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782354 | 0.89 | KDM4E (0.32) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL4739802 | 0.89 | NPC1 (0.32) | NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4737070 | 0.87 | ALDH1A1 (0.36) | LMNAHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4734384 | 0.87 | KMT2A (0.36) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4734073 | 0.86 | CHIA (0.33) | LMNAHPGDNPC1TP53RAB9A | |
| SCHEMBL4740444 | 0.86 | HCAR2 (0.34) | DHODHTP53ALDH1A1 | |
| SCHEMBL4737882 | 0.86 | RAB9A (0.35) | LMNAHPGDNPC1RAB9AKMT2A | |
| SCHEMBL4739107 | 0.86 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL4739132 | 0.84 | KDM4E (0.40) | NPC1RAB9AKDM4E | |
| SCHEMBL4739255 | 0.83 | CHRM2 (0.35) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |