Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734073 | 0.90 | CHIA (0.33) | NPC1RAB9ATP53SMN1; SMN2CCNA2 | |
| SCHEMBL4738609 | 0.89 | DHODH (0.36) | NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL4737882 | 0.89 | RAB9A (0.35) | NPC1RAB9ACCNA2CDK2CCNA1 | |
| SCHEMBL4739132 | 0.87 | KDM4E (0.40) | NPC1RAB9A | |
| SCHEMBL4784972 | 0.87 | NPY5R (0.33) | NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL4737853 | 0.86 | PTGES (0.38) | — | |
| SCHEMBL4782354 | 0.86 | KDM4E (0.32) | — | |
| SCHEMBL4739290 | 0.86 | PDE10A (0.33) | NPC1RAB9A | |
| SCHEMBL4734384 | 0.85 | KMT2A (0.36) | SMN1; SMN2HSP90AA1 | |
| SCHEMBL4737070 | 0.85 | ALDH1A1 (0.36) | NPC1RAB9ASMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |