Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.33 |
| ▸ | HCN1 | O60741 | 5/20 | 0.32 |
| ▸ | HCN4 | Q9Y3Q4 | 3/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739132 | 0.90 | KDM4E (0.40) | RAB9AKDM4EP2RX7NPC1 | |
| SCHEMBL4739802 | 0.90 | NPC1 (0.32) | RAB9ASMN1; SMN2CCNA2CDK2NPC1 | |
| SCHEMBL4737853 | 0.89 | PTGES (0.38) | HCN1HCN4NR3C1P2RX7 | |
| SCHEMBL4737025 | 0.89 | HPGD (0.40) | HCN1HCN4HSD17B10KDM4ELMNA | |
| SCHEMBL4739290 | 0.89 | PDE10A (0.33) | HCN1HCN4RAB9ANPC1 | |
| SCHEMBL4738609 | 0.86 | DHODH (0.36) | RAB9ASMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL4737882 | 0.86 | RAB9A (0.35) | RAB9AHSD17B10KDM4ECCNA2CDK2 | |
| SCHEMBL4737070 | 0.86 | ALDH1A1 (0.36) | RAB9ASMN1; SMN2HSD17B10KDM4ELMNA | |
| SCHEMBL4782354 | 0.84 | KDM4E (0.32) | KDM4E | |
| SCHEMBL4734384 | 0.82 | KMT2A (0.36) | SMN1; SMN2NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | claimed |