Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736673 | 0.87 | ALDH1A1 (0.50) | CYP19A1LMNASMN1; SMN2CYP2C19CYP3A4 | |
| SCHEMBL4738916 | 0.87 | HDAC3 (0.52) | LMNASMN1; SMN2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4737578 | 0.87 | EPHX2 (0.49) | CYP19A1LMNASMN1; SMN2CYP2C19HTT | |
| SCHEMBL4739746 | 0.87 | HDAC3 (0.52) | LMNASMN1; SMN2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4737593 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2CYP2C19CYP3A4HTT | |
| SCHEMBL4736709 | 0.86 | LMNA (0.57) | LMNASMN1; SMN2CYP2C19CYP3A4HTT | |
| SCHEMBL4738253 | 0.85 | MEN1 (0.57) | LMNASMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL4738255 | 0.83 | TSHR (0.58) | LMNASMN1; SMN2TSHRKMT2AHSD11B1 | |
| SCHEMBL4736700 | 0.83 | TSHR (0.58) | LMNASMN1; SMN2TSHRKMT2AHSD11B1 | |
| SCHEMBL4786375 | 0.81 | HSD11B1 (0.62) | LMNATSHRMEN1KMT2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |