Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740126 | 0.93 | CCR1 (0.44) | TSHRPOLBATMHTTNPSR1 | |
| SCHEMBL4736817 | 0.89 | HTT (0.46) | TSHRPOLBATMHSD11B1HTT | |
| SCHEMBL4807472 | 0.84 | CYP3A4 (0.50) | TSHRPOLBHTTNPSR1FLT1 | |
| SCHEMBL4740406 | 0.84 | ALDH1A1 (0.44) | POLBHTTFLT1FLT4KDR | |
| SCHEMBL4741274 | 0.79 | TSHR (0.45) | TSHRPOLBATMHSD11B1HTT | |
| SCHEMBL4741083 | 0.76 | TSHR (0.58) | TSHRPOLBHSD11B1CCR1MAPT | |
| SCHEMBL4736814 | 0.76 | TSHR (0.47) | TSHRPOLBHSD11B1CCR1MAPT | |
| SCHEMBL4740463 | 0.75 | TSHR (0.56) | TSHRPOLBHSD11B1CCR1MAPT | |
| SCHEMBL4736733 | 0.75 | HSD11B1 (0.51) | TSHRHSD11B1HTTNPSR1MAPT | |
| Potassium Ion SCHEMBL4740462 | 0.74 | TSHR (0.55) | TSHRPOLBHSD11B1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |