Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897212 | 0.91 | KDM4E (0.42) | KDM4EGAAPOLBNPC1RAB9A | |
| SCHEMBL14020621 | 0.81 | KDM4E (0.34) | KDM4ENPC1RAB9AMAPTLMNA | |
| SCHEMBL4789019 | 0.75 | SMN1; SMN2 (0.41) | KDM4ENPC1RAB9AMAPTMAPK1 | |
| SCHEMBL3441528 | 0.72 | POLB (0.47) | KDM4EGAAPOLBNPC1RAB9A | |
| SCHEMBL4788948 | 0.72 | KMT2A (0.43) | NPC1RAB9AMAPTLMNASMN1; SMN2 | |
| SCHEMBL4891786 | 0.67 | ALDH1A1 (0.42) | KDM4EPOLBNPC1RAB9AMAPT | |
| SCHEMBL1326886 | 0.67 | KDM4E (0.68) | KDM4EGAAPOLBNPC1RAB9A | |
| SCHEMBL4788013 | 0.66 | ENPP2 (0.43) | MAPTMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4747643 | 0.66 | FFAR2 (0.44) | GAAMAPTLMNANPSR1SMN1; SMN2 | |
| SCHEMBL1897480 | 0.63 | ANO1 (0.61) | KDM4EGAAPOLBMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130313-A1 | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE GABA RECEPTOR FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |