Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751009 | 0.88 | APP (0.50) | ALDH1A1KDM4EAPPSMN1; SMN2MAPT | |
| SCHEMBL4857441 | 0.83 | MEN1 (0.64) | ALDH1A1KDM4ESMN1; SMN2SLC6A7MEN1 | |
| SCHEMBL4751012 | 0.80 | OPRD1 (0.46) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL13982579 | 0.79 | KDM4E (0.52) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4752749 | 0.76 | NPSR1 (0.46) | KDM4EAPPSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4754240 | 0.76 | KDM4E (0.50) | ALDH1A1KDM4EAPPSMN1; SMN2MEN1 | |
| SCHEMBL4799893 | 0.76 | LMNA (0.50) | ALDH1A1APPSMN1; SMN2TP53MAPT | |
| SCHEMBL25233763 | 0.74 | APP (0.44) | ALDH1A1KDM4EAPPSMN1; SMN2KMT2A | |
| SCHEMBL2850013 | 0.73 | ALDH1A1 (0.70) | ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL25232053 | 0.73 | APP (0.43) | ALDH1A1KDM4EAPPSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |