Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HTR1F | P30939 | 4/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4018836 | 0.94 | GRIN1 (0.38) | GRIN1GRIN2BKMT2AMEN1HTR1F | |
| SCHEMBL4749392 | 0.90 | MGLL (0.36) | GRIN1GRIN2BKMT2AMEN1HTR1F | |
| SCHEMBL4752869 | 0.86 | MEN1 (0.40) | KMT2AMEN1MGLL | |
| SCHEMBL4751351 | 0.86 | MEN1 (0.40) | KMT2AMEN1MGLL | |
| SCHEMBL4752891 | 0.85 | ABL1 (0.37) | GRIN1GRIN2BKMT2AMEN1MGLL | |
| SCHEMBL4021646 | 0.84 | MC4R (0.36) | GRIN1GRIN2BKMT2AMEN1MGLL | |
| SCHEMBL4028155 | 0.84 | KMT2A (0.34) | KDM4EKMT2AMEN1TAS1R3TAS1R1 | |
| SCHEMBL4022170 | 0.84 | NPSR1 (0.42) | KDM4EGRIN1GRIN2BKMT2AMEN1 | |
| SCHEMBL4025296 | 0.83 | MGLL (0.35) | GRIN1GRIN2BKMT2AMEN1MGLL | |
| SCHEMBL4022812 | 0.83 | HTR6 (0.35) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |