Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814956 | 0.79 | ALDH1A1 (0.32) | KMT2AMYCNR4A1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4755368 | 0.72 | HCAR2 (0.36) | — | |
| SCHEMBL4758273 | 0.63 | CNR1 (0.39) | GAAMAPTKDM4EMAPK1KMT2A | |
| SCHEMBL28700728 | 0.59 | LMNA (0.41) | GAAMAPTKDM4EMAPK1KMT2A | |
| SCHEMBL1933209 | 0.57 | PDE2A (0.46) | KMT2AMEN1NPC1RAB9ALMNA | |
| Acetic Acid SCHEMBL27591821 | 0.57 | CES2 (0.55) | MAPTMAPK1KMT2AMEN1NPC1 | |
| SCHEMBL21855146 | 0.56 | CA12 (0.43) | LMNARORCPOLB | |
| SCHEMBL3801424 | 0.55 | MEN1 (0.43) | GAAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL15543215 | 0.55 | OPRM1 (0.43) | GAAMAPTKDM4EMAPK1ALDH1A1 | |
| Acetic Acid SCHEMBL27970985 | 0.55 | OPRM1 (0.46) | GAAMAPTKDM4EMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |