Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727352 | 0.91 | GABRA1 (0.37) | GAAKMT2ALMNAHTTPOLB | |
| SCHEMBL3679108 | 0.76 | ACACB (0.43) | HTT | |
| SCHEMBL1579875 | 0.76 | POLB (0.41) | GAAKMT2ALMNAMEN1APAF1 | |
| SCHEMBL3353093 | 0.73 | TDP1 (0.67) | GAAKMT2ALMNATDP1HTT | |
| SCHEMBL647331 | 0.73 | PTGS2 (0.47) | KMT2ALMNAMEN1HSD17B10MMP9 | |
| SCHEMBL3346498 | 0.72 | MAPT (0.47) | HTTALDH1A1MAPTCYP2C19 | |
| SCHEMBL8131978 | 0.72 | SLC1A3 (0.47) | GAAKMT2ALMNAMEN1TDP1 | |
| SCHEMBL11205134 | 0.72 | MAPT (0.47) | HTTALDH1A1MAPTCYP2C19 | |
| SCHEMBL4090652 | 0.71 | HTT (0.68) | KMT2ALMNAMEN1HTTALDH1A1 | |
| SCHEMBL16054222 | 0.70 | KEAP1 (0.36) | GAAKMT2ALMNAMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008004067-A2 | ALPHA-2-DELTA-1 SELECTIVE COMPOUNDS FOR DISORDERS OF THE NERVOUS SYSTEM | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |