Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757333 | 0.86 | OPRM1 (0.36) | NOTUMCCR2 | |
| SCHEMBL4758337 | 0.77 | HSD11B1 (0.36) | NOTUMCCR2 | |
| SCHEMBL4757355 | 0.75 | PYGM (0.39) | NOTUM | |
| SCHEMBL31412247 | 0.62 | ELANE (0.41) | L3MBTL1POLB | |
| SCHEMBL31195695 | 0.60 | ELANE (0.40) | POLB | |
| 1,3,5-Trichlorobenzene SCHEMBL27988562 | 0.60 | FFAR3 (0.56) | NOTUMTPMTL3MBTL1 | |
| SCHEMBL5994409 | 0.55 | ALDH1A1 (0.41) | — | |
| 1,3,5-Trichlorobenzene SCHEMBL28758659 | 0.55 | TPMT (0.57) | NOTUMTPMT | |
| SCHEMBL16591245 | 0.54 | SLC6A3 (0.37) | — | |
| 1,3,5-Trichlorobenzene SCHEMBL5940813 | 0.54 | TSHR (0.67) | TPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |