Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758299 | 0.87 | LMNA (0.42) | OPRM1ALDH1A1TSHRKMT2ACYP2C19 | |
| SCHEMBL4757340 | 0.86 | NOTUM (0.34) | CCR2NOTUM | |
| SCHEMBL4758337 | 0.86 | HSD11B1 (0.36) | OPRM1CCR2TSHRAKR1B1NOTUM | |
| SCHEMBL4758254 | 0.84 | HCAR3 (0.39) | ALDH1A1CCR2SMN1; SMN2TSHRHPGD | |
| SCHEMBL4758286 | 0.81 | TSHR (0.36) | ALDH1A1SMN1; SMN2TSHRNOTUM | |
| SCHEMBL4758583 | 0.80 | PYGL (0.38) | GAAALDH1A1TSHRKMT2AAKR1B1 | |
| SCHEMBL4757355 | 0.78 | PYGM (0.39) | GAAALDH1A1CYP2C19NOTUM | |
| SCHEMBL4756162 | 0.76 | TDP1 (0.40) | OPRM1ALDH1A1CCR2TSHRKMT2A | |
| SCHEMBL4756152 | 0.72 | LMNA (0.33) | OPRM1ALDH1A1SMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL4758585 | 0.69 | FPR2 (0.37) | ALDH1A1CCR2SMN1; SMN2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006070-A2 | COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF | ROSKAMP RESEARCH LLC (US) | 2008-01-10 | — | — | WO | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |