Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31322341 | 0.82 | HTR6 (0.66) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL21442594 | 0.78 | DRD2 (0.71) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL3454087 | 0.77 | HTR6 (0.70) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL13365285 | 0.77 | ALDH1A1 (0.59) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL28015570 | 0.74 | HTR6 (0.56) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL6798179 | 0.74 | MBTD1 (0.59) | HTR6PKM | |
| SCHEMBL266849 | 0.74 | PKM (0.67) | POLBPKMHTTMAPK1LMNA | |
| SCHEMBL12719397 | 0.74 | HTR6 (0.70) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL30754642 | 0.74 | TDO2 (0.60) | HTR6HTR1AHTR2AHTR7DRD2 | |
| SCHEMBL6224554 | 0.74 | PKM (0.67) | POLBPKMHTTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981848-A2 | 11-BETA HSD1 INHIBITORS | Wyeth (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092435-A2 | 11-BETA HSD1 INHIBITORS | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |