Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL20496113 | 0.97 | ALOX12 (0.47) | ALOX12CYP2A6KEAP1L3MBTL1TSHR | |
| Naphthalene SCHEMBL27549394 | 0.97 | ALOX12 (0.47) | ALOX12CYP2A6KEAP1L3MBTL1TSHR | |
| Anthracene SCHEMBL21295279 | 0.88 | L3MBTL1 (0.48) | KEAP1L3MBTL1TSHRSMN1; SMN2ATM | |
| Naphthalene SCHEMBL672294 | 0.87 | ALOX12 (0.57) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL2678900 | 0.87 | ALOX12 (0.57) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL28674544 | 0.87 | ALOX12 (0.57) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL5574575 | 0.87 | ALOX12 (0.57) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL29361795 | 0.87 | ALOX12 (0.57) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL8773082 | 0.84 | ALOX12 (0.53) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 | |
| Naphthalene SCHEMBL9484717 | 0.84 | ALOX12 (0.53) | ALOX12CYP2A6L3MBTL1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102159201-A | 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases | MERZ PHARMA GMBH & CO KGAA | 2011-08-17 | — | — | CN | claimed |
| CN-101913830-A | Novel autoclaved fly ash self-insulation wall material and production process | HENAN RES INST OF BUILDING SCIENCE CO LTD | 2010-12-15 | — | — | CN | claimed |
| CN-1127563-C | water-soluble granules of phthalocyanine compounds | CIBA SC HOLDING AG (CH) | 2003-11-12 | — | — | CN | claimed |
| CN-1236006-A | Water-soluble granules of phthalocyanine compounds | CIBA SC HOLDING AG (CH) | 1999-11-24 | — | — | CN | claimed |
| CN-118439976-B | Nafamostat mesylate crystal form and preparation method thereof | 南京海纳医药科技股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-119137264-A | Bacteria of the genus Xanthomonas bacteriolytic phage | 株式会社钟化 | 2024-12-13 | — | — | CN | disclosed |
| CN-118439976-A | Nafamostat mesylate crystal form and preparation method thereof | 南京海纳医药科技股份有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-118234496-A | Improved treatment of advanced/metastatic cancers with checkpoint inhibitor resistance or drug resistance susceptibility | 海南先声再明医药股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-118103064-A | Methods of treating sickle cell disease or beta thalassemia with inhibitors of the alternative complement pathway | 阿雷克森制药公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117948096-A | Method and system for improving recovery ratio of foam oil reservoir | 中国石油天然气股份有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-117915942-A | Methods of treating sickle cell disease or beta thalassemia with inhibitors of the alternative complement pathway | 阿雷克森制药公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117677399-A | Effective ASGPR binding compounds for the degradation of immunoglobulins and other proteins | 阿维拉治疗公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-1390210-A | Method for producing oxazoline compound from tetrahydrofuran compound | AGOURON PHARMA (US) | 2003-01-08 | — | — | CN | disclosed |
| CN-1365383-A | Water-soluble granules of salen-type manganese cmplexes | CIBA SC HOLDING AG (CH) | 2002-08-21 | — | — | CN | disclosed |
| CN-1355790-A | Method for inhibiting amyloid aggregation and imaging amyloid deposits using isoindoline derivatives | WARNER LAMBERT CO (US) | 2002-06-26 | — | — | CN | disclosed |
| CN-1349381-A | Sulfonamide derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-15 | — | — | CN | disclosed |
| CN-1333698-A | Combination chemotherapy | WARNER LAMBERT CO (US) | 2002-01-30 | — | — | CN | disclosed |
| CN-1306515-A | Combinations of protein farnesyltransferase and HMG COA reductase inhibitors and their use to treat cancer | WARNER LAMBERT CO (US) | 2001-08-01 | — | — | CN | disclosed |
| CN-1236006-A | Water-soluble granules of phthalocyanine compounds | CIBA SC HOLDING AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| CN-1168631-A | Methods for treating resistant tumors | LILLY CO ELI (US) | 1997-12-24 | — | — | CN | disclosed |