Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120239 | 0.89 | HTR6 (0.40) | NAMPTALDH1A1L3MBTL1 | |
| SCHEMBL4126131 | 0.88 | HTT (0.37) | NAMPTALDH1A1L3MBTL1 | |
| SCHEMBL476471 | 0.88 | NAMPT (0.35) | NAMPTALDH1A1L3MBTL1 | |
| SCHEMBL18258908 | 0.87 | NAMPT (0.35) | NAMPTKAT6AALDH1A1L3MBTL1 | |
| SCHEMBL4137822 | 0.85 | HTR2A (0.39) | NAMPTRORCKAT6A | |
| SCHEMBL4139027 | 0.85 | CNR1 (0.39) | NAMPTRORC | |
| SCHEMBL476390 | 0.85 | HTT (0.39) | NAMPTALDH1A1 | |
| SCHEMBL4125767 | 0.85 | NFE2L2 (0.39) | NAMPTGLO1SLC40A1 | |
| SCHEMBL476373 | 0.84 | GLO1 (0.39) | NAMPTGLO1SLC40A1APLNR | |
| SCHEMBL476365 | 0.84 | APLNR (0.35) | NAMPTGLO1SLC40A1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412713-B1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2016-11-30 | — | — | EP | disclosed |
| EP-2412713-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2012-02-01 | — | — | EP | disclosed |