Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.46 |
| ▸ | KDR | P35968 | 12/20 | 0.46 |
| ▸ | IGF1R | P08069 | 5/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771089 | 0.95 | MET (0.49) | METKDRIGF1RINSRAURKA | |
| Trifluoroacetic Acid SCHEMBL4774586 | 0.83 | MAPT (0.51) | METALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4766836 | 0.80 | SLC2A1 (0.44) | ALDH1A1SMN1; SMN2SLC2A1AXL | |
| Trifluoroacetic Acid SCHEMBL4764992 | 0.80 | TP53 (0.51) | METMEN1ALDH1A1MAPTKMT2A | |
| Trifluoroacetic Acid SCHEMBL4775487 | 0.78 | KMT2A (0.53) | MEN1ALDH1A1KMT2ASLC2A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4768481 | 0.78 | NPY5R (0.49) | JAK3SLC2A1 | |
| SCHEMBL4773051 | 0.77 | MAPT (0.56) | METALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4765180 | 0.77 | POLB (0.52) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL4771045 | 0.77 | RAB9A (0.53) | MEN1KMT2ASMN1; SMN2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL4768193 | 0.77 | MAPT (0.45) | ALDH1A1MAPTKMT2ASMN1; SMN2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | claimed |
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | MET 3458/4885KDR 3994/4885IGF1R 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.