Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 3/20 | 0.50 |
| ▸ | TUBB | P07437 | 3/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314819 | 0.87 | ALDH1A1 (0.46) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1264565 | 0.83 | TUBB4A (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4574250 | 0.81 | HTT (0.48) | ALDH1A1MEN1MAPTKMT2AIL2 | |
| SCHEMBL31063362 | 0.81 | KDM1A (0.54) | TUBB1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4574438 | 0.81 | IL2 (0.45) | ALDH1A1F2PLGPLAUPLAT | |
| SCHEMBL13362064 | 0.81 | HTR2C (0.54) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL520088 | 0.79 | QDPR (0.64) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL15157184 | 0.79 | HTR1D (0.38) | MEN1KMT2ATDP1 | |
| SCHEMBL30432645 | 0.79 | HTR1D (0.38) | MEN1KMT2ATDP1 | |
| SCHEMBL12856197 | 0.79 | QDPR (0.44) | ALDH1A1IL2MAP4K1NR3C1QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636217-B1 | 2-IMIDAZO-BENZOTHIAZOLES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-09-03 | — | — | EP | disclosed |
| US-7371748-B2 | Benzothiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371748-B2 | Benzothiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371748-B2 | Benzothiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| WO-2008052930-A2 | PREPARATION OF 4-ALK0XY-7- (TETRAHYDROPYRAN-4-YL) BENZOTHIAZOL-2-AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | disclosed |
| US-20080108826-A1 | PREPARATION OF 4-ALKOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YLAMINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-05-08 | — | — | US | disclosed |
| US-20080108826-A1 | PREPARATION OF 4-ALKOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YLAMINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-05-08 | — | — | US | disclosed |
| EP-1636223-B1 | BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-7304058-B2 | For therapy of Alzheimer's disease, depression | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304058-B2 | For therapy of Alzheimer's disease, depression | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-20040235915-A1 | Benzothiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | US | disclosed |
| US-20040235915-A1 | Benzothiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | US | disclosed |
| US-20040235915-A1 | Benzothiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | US | disclosed |
| WO-2004101558-A1 | 2-IMIDAZO-BENZOTHIAZOLES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | WO | disclosed |
| US-20040235842-A1 | Carbamic acid esters of benzothiazoles | F. HOFFMANN-LA ROCHE AG (CH) | 2004-11-25 | — | — | US | disclosed |
| US-20040229862-A1 | Imidazo-benzothiazoles | F. HOFFMAN-LA ROCHE AG (CH) | 2004-11-18 | — | — | US | disclosed |
| EP-1456202-A1 | BENZOTHIAZOLES | F. Hoffman-la Roche AG (CH) | 2004-09-15 | — | — | EP | disclosed |
| US-6734179-B2 | SULFUR COMPOUNDS SUCH AS 4-FLUORO-N-(4-METHOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YL) -BENZAMIDE, USED AS PREFERENTIAL ADENOSINE RECEPTOR LIGANDS FOR THE PROPHYLAXIS OF NEURODEGENERATIVE DISORDERS | HOFFMANN-LA ROCHE INC. | 2004-05-11 | — | — | US | disclosed |
| US-20030144288-A1 | Benzothiazoles | F. HOFFMAN-LA ROCHE AG A SWISS COMPANY (CH) | 2003-07-31 | — | — | US | disclosed |
| WO-2003053961-A1 | BENZOTHIAZOLES | F. HOFFMAN-LA ROCHE AG (CH) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235915-A1 | Benzothiazole derivatives | ADORA1, ADORA2A, ADORA3 | TUBB4A 2629/4885TUBB 2572/4885TUBA3C 3436/4885 |
| US-20040235842-A1 | Carbamic acid esters of benzothiazoles | ADORA2A, ADORA1, ADORA2B | TUBB4A 2541/4885TUBB 3373/4885TUBA3C 3249/4885 |
| US-20080108826-A1 | PREPARATION OF 4-ALKOXY-7-(TETRAHYDRO-PYRAN-4-YL)-BENZOTHIAZOL-2-YLAMINE DERIVATIVES | HTR7, HTR4, BRD7 | TUBB4A 342/4885TUBB 860/4885TUBA3C 993/4885 |
| US-20030144288-A1 | Benzothiazoles | ADORA2A, ADORA1, ADORA2B | TUBB4A 2069/4885TUBB 2462/4885TUBA3C 2788/4885 |
| US-20040229862-A1 | Imidazo-benzothiazoles | ADORA1, ADORA3, ADORA2A | TUBB4A 3447/4885TUBB 4111/4885TUBA3C 3762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.