SCHEMBL476873

SCHEMBL476873

O=C(Cl)c1c(F)cccc1Cl

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.71
GAA P10253 8/20 0.56
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
JAK2 O60674 1/20 0.51
JAK1 P23458 1/20 0.51
TYK2 P29597 1/20 0.51
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
ALOX15 P16050 1/20 0.48
LMNA P02545 1/20 0.47
PKM P14618 1/20 0.47
TLR7 Q9NYK1 1/20 0.47
MAPT P10636 1/20 0.47
RAB9A P51151 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
POLB P06746 1/20 0.46
HPGD P15428 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL105255 0.86 CES2 (0.64) ALDH1A1GAACES2CES1JAK2
SCHEMBL2876974 0.84 GAA (0.58) ALDH1A1GAACES2CES1JAK2
SCHEMBL15578239 0.84 CES2 (0.61) ALDH1A1GAACES2CES1JAK2
SCHEMBL103586 0.84 ALDH1A1 (1.00) ALDH1A1GAACES2CES1JAK2
SCHEMBL695459 0.83 GAA (0.56) ALDH1A1GAACES2CES1JAK2
SCHEMBL29570977 0.83 GAA (0.56) ALDH1A1GAACES2CES1JAK2
SCHEMBL11179271 0.83 GAA (0.56) ALDH1A1GAACES2CES1JAK2
Methane SCHEMBL28290707 0.81 ALDH1A1 (0.95) ALDH1A1GAACES2CES1JAK2
SCHEMBL716550 0.81 GAA (0.54) ALDH1A1GAACES2CES1JAK2
SCHEMBL29443043 0.81 GAA (0.54) ALDH1A1GAACES2CES1JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 507 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110818556-A Method for producing high-purity 2-chloro-6-fluorobenzoyl chloride by using waste residues 浙江大洋生物科技集团股份有限公司 2020-02-21 CN claimed
EP-1506176-B1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2013-04-24 EP claimed
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors INCYTE CORPORATION (US) 2026-02-17 US disclosed
US-12545682-B2 Heterocyclic derivatives as P2X7 receptor antagonists BREYE THERAPEUTICS APS (DK) 2026-02-10 US disclosed
EP-4665705-A1 A PROCESSES FOR THE PREPARATION OF BENZONITRILE COMPOUNDS FROM THE CORRESPONDING BENZOTRICHLORIDE COMPOUNDS Aarti Industries Limited (IN) 2025-12-24 EP disclosed
US-12410174-B1 Small molecular inhibitors of sting signaling compositions and methods of use TYERELL IMMUNOTHERAPEUTICS INC (US) 2025-09-09 US disclosed
EP-4541422-A2 QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS Gilead Sciences, Inc. (US) 2025-04-23 EP disclosed
WO-2025061035-A1 BRM SELECTIVE DEGRADATION AGENT COMPOUND AND USE THEREOF 南京再明医药有限公司 2025-03-27 WO disclosed
EP-4262975-B1 HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS BREYE THERAPEUTICS APS (DK) 2025-03-05 EP disclosed
CN-119462635-A Quinoline derivatives as alpha 4 beta 7 integrin inhibitors 吉利德科学公司 2025-02-18 CN disclosed
US-20250032473-A1 QUINOLINE DERIVATIVES GILEAD SCIENCES, INC. 2025-01-30 US disclosed
EP-0261459-A2 N-benzothiazolyl amides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1988-03-30 EP disclosed
EP-0113151-B1 PRINTING MEDIUM AND USE THEREOF International Business Machines Corporation (US) 1988-03-09 EP disclosed
US-4675331-A INSECTICIDE NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-06-23 US disclosed
EP-0208321-A2 Triazole derivatives, their preparation and their use as pesticides CIBA-GEIGY AG (CH) 1987-01-14 EP disclosed
CN-86102102-A Preparation technology of new benzamides and uses thereof 1987-01-07 CN disclosed
EP-0196547-A1 Benzamides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1986-10-08 EP disclosed
EP-0113151-A2 Printing medium and use thereof International Business Machines Corporation (US) 1984-07-11 EP disclosed
US-4297361-A PREFERENTIAL ACTIVITY AGAINST BEETLES, MOTHS, AND FLIES SCHERING AKTIENGESELLSCHAFT (DE) 1981-10-27 US disclosed
US-4277499-A Combating insects with N-(substituted-phenyl)-N-(2-chloro-6-fluoro-benzoyl)-ureas BAYER AKTIENGESELLSCHAFT (DE) 1981-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12410174-B1 Small molecular inhibitors of sting signaling compositions and methods of use STING1, IRF3, MAVS ALDH1A1 4833/4885GAA 1184/4885CES2 4707/4885
US-12545682-B2 Heterocyclic derivatives as P2X7 receptor antagonists P2RX7, P2RX3, P2RX1 ALDH1A1 1416/4885GAA 4666/4885CES2 1858/4885
US-12552804-B2 Tricyclic heterocycles as FGFR inhibitors FGFR3, FGFR1, FGFR2 ALDH1A1 478/4885GAA 2760/4885CES2 1727/4885
US-20250032473-A1 QUINOLINE DERIVATIVES CFTR, NQO1, IRF3 ALDH1A1 476/4885GAA 252/4885CES2 1985/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.