Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.42 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776778 | 0.86 | NFE2L2 (0.44) | VCPLTB4RPTGS2MAPTPTGS1 | |
| SCHEMBL4774611 | 0.82 | LTB4R (0.47) | CYP19A1CYP11B1CYP11B2LTB4RPTGS2 | |
| SCHEMBL4776218 | 0.81 | CYP19A1 (0.42) | CYP19A1CYP11B1CYP11B2LTB4RCNR2 | |
| SCHEMBL4795011 | 0.77 | PTGIR (0.38) | PTGS2 | |
| SCHEMBL4779682 | 0.76 | PLA2G2A (0.41) | CYP19A1CYP11B1CYP11B2LTB4RPTGS2 | |
| SCHEMBL4779677 | 0.74 | EIF4A1 (0.43) | CYP19A1CYP11B1CYP11B2LTB4RMAPT | |
| SCHEMBL4778107 | 0.72 | LTB4R (0.48) | CYP19A1CYP11B1CYP11B2LTB4RCNR2 | |
| SCHEMBL4779650 | 0.71 | MAPT (0.46) | CYP19A1CYP11B1CYP11B2LTB4RMAPT | |
| SCHEMBL4778477 | 0.70 | MEN1 (0.45) | CYP19A1CYP11B1CYP11B2LTB4RPTGS2 | |
| SCHEMBL4774580 | 0.69 | GRIN2B (0.40) | CYP19A1CYP11B1CYP11B2CNR2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |