Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774683 | 0.85 | NOS3 (0.39) | LMNARAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL4776439 | 0.79 | SPHK1 (0.35) | LMNAHTTEPHX1MAPTALDH1A1 | |
| SCHEMBL4794914 | 0.76 | ADRA2A (0.45) | — | |
| SCHEMBL4774754 | 0.72 | PDE5A (0.41) | GRIN2BHTTKMT2APOLBCYP19A1 | |
| SCHEMBL4780410 | 0.72 | NOS3 (0.44) | GRIN2BKMT2APOLBCYP19A1EPHX1 | |
| SCHEMBL4779107 | 0.69 | PDE5A (0.47) | LMNAHTTKMT2ACYP19A1EPHX1 | |
| SCHEMBL4774562 | 0.69 | CYP19A1 (0.42) | GRIN2BLMNAMEN1KMT2ASIGMAR1 | |
| SCHEMBL4780673 | 0.68 | CYP11B1 (0.45) | HTTMEN1KMT2APOLBCYP19A1 | |
| SCHEMBL4774100 | 0.68 | NOS3 (0.42) | LMNAMEN1KMT2APOLBSIGMAR1 | |
| SCHEMBL4778107 | 0.68 | LTB4R (0.48) | MEN1KMT2APOLBCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |