Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.33 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780443 | 0.85 | PDE5A (0.38) | SPHK1ALDH1A1PDE5A | |
| SCHEMBL4796379 | 0.85 | PDE5A (0.38) | SPHK1ALDH1A1PDE5A | |
| SCHEMBL4776487 | 0.85 | PDE5A (0.38) | SPHK1ALDH1A1PDE5A | |
| SCHEMBL4774683 | 0.85 | NOS3 (0.39) | MAPTALDH1A1LMNAMCHR1PDE5A | |
| SCHEMBL4780605 | 0.80 | BRAF (0.38) | MAPTALDH1A1SMN1; SMN2LMNAPDE5A | |
| SCHEMBL4794914 | 0.79 | ADRA2A (0.45) | — | |
| SCHEMBL4774580 | 0.79 | GRIN2B (0.40) | MAPTHTTALDH1A1LMNAEPHX1 | |
| SCHEMBL14303801 | 0.74 | KDM4E (0.40) | MAPTALDH1A1SMN1; SMN2EPHX1 | |
| SCHEMBL4780429 | 0.72 | MOK (0.42) | MAPTALDH1A1SMN1; SMN2EPHX1 | |
| SCHEMBL4774754 | 0.72 | PDE5A (0.41) | HTTEPHX1OPRM1PDE5AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |