Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776706 | 0.88 | PLA2G2A (0.42) | HRH2HRH3PLA2G2APLA2G10PLA2G1B | |
| SCHEMBL4779671 | 0.88 | EIF4A1 (0.40) | PLA2G2APLA2G10PLA2G1BPLA2G5LTB4R | |
| SCHEMBL4776700 | 0.85 | HRH2 (0.42) | HRH2HRH3PLA2G2APLA2G10PLA2G1B | |
| SCHEMBL4774672 | 0.76 | NOS3 (0.43) | HRH2HRH3NOS3NOS1NOS2 | |
| SCHEMBL4779682 | 0.76 | PLA2G2A (0.41) | PLA2G2APLA2G10PLA2G1BPLA2G5LTB4R | |
| SCHEMBL4774626 | 0.74 | NOS3 (0.43) | HRH2HRH3NOS3NOS1NOS2 | |
| SCHEMBL4779677 | 0.73 | EIF4A1 (0.43) | PLA2G2APLA2G10PLA2G1BPLA2G5L3MBTL1 | |
| SCHEMBL4793947 | 0.68 | ADRA2A (0.40) | — | |
| SCHEMBL4778112 | 0.68 | NOS3 (0.47) | NOS3NOS1NOS2LTB4RDHODH | |
| SCHEMBL18511748 | 0.67 | PLA2G2A (0.54) | PLA2G2APLA2G10PLA2G1BPLA2G5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009963-A2 | PYRIMIDINE DERIVATIVES AS MODULATORS OF PARATHYROID HORMONE RECEPTORS | JAMES BLACK FOUNDATION LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |