Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 15/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784135 | 0.89 | CYP1A2 (0.48) | NR1I2MAPK1TSHRHTT | |
| SCHEMBL4779770 | 0.89 | NR1H4 (0.39) | NR1I2TSHR | |
| SCHEMBL4778554 | 0.84 | DDT (0.42) | NR1I2 | |
| SCHEMBL4780940 | 0.83 | DRD2 (0.34) | NR1I2 | |
| SCHEMBL4783718 | 0.81 | LMNA (0.36) | NR1I2HTT | |
| SCHEMBL4778561 | 0.79 | DDT (0.45) | NR1I2 | |
| SCHEMBL13843780 | 0.78 | NR1I2 (0.41) | NR1I2 | |
| SCHEMBL4779207 | 0.77 | NR1I2 (0.38) | NR1I2 | |
| SCHEMBL4783370 | 0.77 | DDT (0.38) | — | |
| SCHEMBL4799754 | 0.77 | MAPK14 (0.37) | NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |