Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785401 | 0.85 | SFRP1 (0.54) | SFRP1MEN1KMT2AALDH1A1 | |
| SCHEMBL4784223 | 0.84 | HTR1A (0.42) | SFRP1 | |
| SCHEMBL4782531 | 0.82 | SFRP1 (0.53) | SFRP1MEN1KMT2AALDH1A1POLB | |
| SCHEMBL4783673 | 0.80 | CCR8 (0.51) | ALDH1A1USP2 | |
| SCHEMBL14208234 | 0.80 | HTR6 (0.49) | SFRP1ALDH1A1 | |
| SCHEMBL4802468 | 0.80 | HTR1A (0.46) | CYP3A4 | |
| SCHEMBL4781850 | 0.79 | SFRP1 (0.44) | SFRP1MEN1KMT2A | |
| SCHEMBL4782745 | 0.79 | SFRP1 (0.52) | SFRP1 | |
| SCHEMBL14207899 | 0.78 | HTR6 (0.43) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4784467 | 0.77 | HTR6 (0.42) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |