Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.69 |
| ▸ | CES1 | P23141 | 3/20 | 0.69 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.56 |
| ▸ | FEN1 | P39748 | 1/20 | 0.56 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189871 | 0.82 | PARP10 (0.69) | CES2CES1ERCC5FEN1PARP10 | |
| SCHEMBL4625390 | 0.82 | CES2 (1.00) | CES2CES1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL7669290 | 0.82 | CES2 (1.00) | CES2CES1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL1269735 | 0.81 | ERCC5 (0.64) | ERCC5FEN1PARP10SRD5A2HDAC3 | |
| SCHEMBL9242631 | 0.81 | CES2 (0.68) | CES2CES1ERCC5FEN1PARP10 | |
| SCHEMBL2360203 | 0.79 | CES2 (0.69) | CES2CES1PARP10HDAC3 | |
| SCHEMBL4739675 | 0.79 | ALDH1A1 (0.57) | CES2CES1ERCC5FEN1PARP10 | |
| SCHEMBL9807208 | 0.79 | PARP10 (0.64) | CES2CES1ERCC5FEN1PARP10 | |
| SCHEMBL4166171 | 0.79 | PARP10 (0.64) | CES2CES1ERCC5FEN1PARP10 | |
| SCHEMBL2134251 | 0.78 | CES2 (0.71) | CES2CES1ERCC5FEN1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008077646-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-07-03 | — | — | WO | disclosed |