Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785325 | 0.81 | TDP1 (0.51) | LMNASMN1; SMN2TP53HTTKMT2A | |
| SCHEMBL4784743 | 0.80 | HTR6 (0.41) | LMNASMN1; SMN2HSD17B10HTTMAPT | |
| SCHEMBL4782672 | 0.78 | ALDH1A1 (0.37) | LMNASMN1; SMN2KDM4E | |
| SCHEMBL4782361 | 0.78 | TBXAS1 (0.46) | SMN1; SMN2KMT2A | |
| SCHEMBL4783079 | 0.77 | AKR1C3 (0.45) | MAPTKMT2A | |
| SCHEMBL4783275 | 0.75 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2HTT | |
| SCHEMBL22633565 | 0.74 | GAA (0.61) | LMNASMN1; SMN2GAAHSD17B10CHRM1 | |
| SCHEMBL4784894 | 0.73 | KMT2A (0.44) | SMN1; SMN2KMT2ATSHR | |
| SCHEMBL4781323 | 0.71 | HTR6 (0.43) | LMNASMN1; SMN2HTTKMT2ATSHR | |
| SCHEMBL4785309 | 0.71 | HTR6 (0.43) | LMNASMN1; SMN2HTTKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |