Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788575 | 0.78 | GAA (0.49) | ALDH1A1CYP2C9CYP2C19HSD17B10KDM4E | |
| SCHEMBL4788014 | 0.65 | MAPT (0.41) | PKMALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL7688461 | 0.65 | KMT2A (0.65) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL27707738 | 0.65 | NFE2L2 (0.49) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL10112995 | 0.62 | ALDH1A1 (0.66) | ALDH1A1CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL10280120 | 0.62 | DHFR (0.53) | PKMALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL490336 | 0.61 | MAPT (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL21668045 | 0.61 | KDM4E (0.42) | PKMALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL10455857 | 0.61 | CA12 (0.63) | ALDH1A1CYP2C9MEN1KMT2AKDM4E | |
| SCHEMBL27681080 | 0.60 | LMNA (0.49) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |