Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 10/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.38 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.35 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790266 | 0.83 | CDK9 (0.42) | PRPS1CDK9 | |
| SCHEMBL4792620 | 0.77 | CDK9 (0.39) | PRPS1CDK9QPCTQPCTLCCR3 | |
| SCHEMBL4792148 | 0.74 | CDK9 (0.42) | PRPS1CDK9 | |
| SCHEMBL4793189 | 0.73 | HRH3 (0.40) | PRPS1CDK9KCNH2 | |
| SCHEMBL2882039 | 0.72 | ALDH1A1 (0.42) | PRPS1QPCTQPCTLKCNH2 | |
| SCHEMBL4237634 | 0.71 | SLC6A2 (0.50) | CHI3L1 | |
| SCHEMBL3724429 | 0.71 | SLC6A2 (0.50) | CHI3L1 | |
| SCHEMBL4765961 | 0.70 | HRH3 (0.48) | PRPS1QPCTQPCTL | |
| SCHEMBL5193918 | 0.70 | HTR3A (0.40) | CHI3L1KCNH2CHIT1CHIA | |
| SCHEMBL2879067 | 0.69 | HRH3 (0.52) | PRPS1QPCTQPCTL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |