Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MTTP | P55157 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881694 | 0.70 | DGAT2 (0.40) | DGAT2KMT2ATRPV1ITKHTT | |
| SCHEMBL4771179 | 0.69 | GAA (0.47) | DGAT2NAMPT | |
| SCHEMBL4773432 | 0.67 | MEN1 (0.46) | MEN1KMT2ATRPV1ITKP2RX7 | |
| SCHEMBL4772464 | 0.66 | GAA (0.48) | DGAT2NAMPT | |
| SCHEMBL4777619 | 0.65 | NAMPT (0.42) | DGAT2TRPV1P2RX7NAMPT | |
| SCHEMBL4773601 | 0.64 | MAPT (0.39) | DGAT2MEN1KMT2AHTTRORC | |
| SCHEMBL4773435 | 0.64 | ALDH1A1 (0.48) | MEN1KMT2ATRPV1HTTP2RX7 | |
| SCHEMBL4776574 | 0.64 | P2RX7 (0.42) | DGAT2TRPV1P2RX7NAMPT | |
| SCHEMBL4875601 | 0.64 | NPC1 (0.50) | HTT | |
| SCHEMBL4776579 | 0.64 | GAA (0.42) | DGAT2HTTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | claimed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |