Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.45 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10045634 | 0.89 | SIGMAR1 (0.44) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL1261202 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| Bromide SCHEMBL1047245 | 0.81 | CSNK1E (0.46) | CNR2HTR2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9347571 | 0.81 | CSNK1E (0.46) | CNR2HTR2ASMN1; SMN2 | |
| Water SCHEMBL9244237 | 0.81 | CSNK1E (0.46) | CNR2HTR2ASMN1; SMN2 | |
| SCHEMBL15022959 | 0.80 | ANPEP (0.52) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL11752094 | 0.80 | CNR2 (0.48) | ALDH1A1HPGDALOX15ALOX12CASP1 | |
| SCHEMBL6729364 | 0.80 | TSHR (0.48) | ALDH1A1HPGDCNR2SMN1; SMN2TSHR | |
| SCHEMBL17807999 | 0.80 | TSHR (0.48) | ALDH1A1HPGDCNR2SMN1; SMN2TSHR | |
| SCHEMBL28721827 | 0.80 | CNR2 (0.44) | ALDH1A1HPGDALOX15ALOX12CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083873-B1 | HETEROCYCLIC THIOESTER AND KETONE HAIR GROWTH COMPOSITIONS AND USES | MGI GP INC (US) | 2006-08-09 | — | — | EP | claimed |
| US-7410995-B1 | N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders | GPI NIL HOLDINGS INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| EP-1479373-A1 | Hair growth compositions and uses | GPI NIL Holdings, Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | disclosed |
| EP-0983054-B1 | HAIR GROWTH COMPOSITIONS AND USES | GUILFORD PHARM INC (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | disclosed |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-10-30 | — | — | US | disclosed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | disclosed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| EP-1085854-A1 | N-LINKED SULFONAMIDE OF HETEROCYCLIC THIOESTER HAIR GROWTH COMPOUNDS AND USES | GPI NIL Holdings, Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6187806-B1 | 3-PHENYLPROPYL(2S)-N-(BENZYLSULFONYL)PYRROLIDINE-2-CARBOXYTHIOATE, FOR EXAMPLE AND OTHER COMPOUNDS THAT HAVE AN AFFINITY FOR AN FKBP-TYPE IMMUNOPHILIN AND ARE NON-IMMUNOSUPPRESSIVE; FOR TREATING ALOPECIA | GPI NIL HOLDINGS | 2001-02-13 | — | — | US | disclosed |
| EP-1011650-A1 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | Amgen Inc., (US) | 2000-06-28 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-2000009108-A2 | COMPOSITIONS AND USES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| WO-2000009107-A2 | SULFONAMIDES OF N-CONTAINING HETEROCYCLIC THIOESTERS FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| US-6004993-A | TREATMENT OF ALOPECIA IN ANIMALS | GPI NIL HOLDINGS, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| WO-1999062489-A1 | N-LINKED SULFONAMIDE OF HETEROCYCLIC THIOESTER HAIR GROWTH COMPOUNDS AND USES | GPI NIL HOLDINGS, INC. (US) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999014998-A2 | METHOD FOR PREVENTING AND TREATING HEARING LOSS USING SENSORINEUROTROPHIC COMPOUNDS | AMGEN INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| US-5874449-A | INHIBITORS OF IMMUNOPHILIN | GPI NIL HOLDINGS, INC. (US) | 1999-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | ALDH1A1 508/4885HPGD 532/4885ALOX15 1955/4885 |
| US-20030203890-A1 | Method for treating nerve injury caused as a result of surgery | NGF, BDNF, GAP43 | ALDH1A1 824/4885HPGD 424/4885ALOX15 1698/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | ALDH1A1 757/4885HPGD 71/4885ALOX15 1800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.