SCHEMBL48043

SCHEMBL48043

CC1(O)C(=O)NC(=O)NC1O

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.32
MMP2 P08253 1/20 0.31
MMP9 P14780 1/20 0.31
TDP2 O95551 1/20 0.31
MAPT P10636 1/20 0.31
SMAD3 P84022 1/20 0.31
HSD17B10 Q99714 1/20 0.31
KDM4C Q9H3R0 1/20 0.31
LMNA P02545 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14687576 1.00 TSHR (0.34) TSHRHTTMMP2MMP9TDP2
SCHEMBL18132317 0.76 TSHR (0.32) TSHR
SCHEMBL11616770 0.76 TSHR (0.33) TSHRHTTMMP2MMP9
SCHEMBL10827106 0.70 PYGM (0.34) TSHR
SCHEMBL21030508 0.70 LMNA (0.41) TSHRHTTLMNA
SCHEMBL14874449 0.67
SCHEMBL11616499 0.67
SCHEMBL23462596 0.65
SCHEMBL11243781 0.65 TP53 (0.37) TSHRKMT2A
SCHEMBL11239122 0.64 HTT (0.30) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630851-B2 Polynucleotide modification methods OXFORD NANOPORE TECHNOLOGIES PLC (GB) 2026-05-19 US claimed
US-20260098287-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS CHENG-YAO CHEN (TW) 2026-04-09 US claimed
US-12577615-B2 Methods for the detection of a nucleic acid RHODX, INC. (US) 2026-03-17 US claimed
WO-2025245282-A1 COMPOSITIONS AND METHODS FOR DETECTION OF PROTEIN ANALYTES RANGE BIOTECHNOLOGIES, INC. (US) 2025-11-27 WO claimed
US-20250340935-A1 METHODS FOR THE DETECTION OF A NUCLEIC ACID RHODX INC (US) 2025-11-06 US claimed
EP-4569132-A2 METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS Chen, Cheng-Yao (TW) 2025-06-18 EP claimed
WO-2025021984-A1 METHOD FOR GENERATING A PLURALITY OF POLYNUCLEOTIDES DNA SCRIPT (FR) 2025-01-30 WO claimed
US-20250019744-A1 METHOD, KIT AND SYSTEM FOR END LABELING OF NUCLEIC ACIDS Chen, Cheng-Yao (TW) 2025-01-16 US claimed
US-12084715-B1 Methods and systems for reducing artifactual antisense products 10X GENOMICS, INC. (US) 2024-09-10 US claimed
WO-2024138550-A1 NUCLEIC ACID AMPLIFICATION METHOD AND USE THEREOF IN SEQUENCING 深圳华大智造科技股份有限公司 2024-07-04 WO claimed
WO-2001051669-A9 NUCLEIC ACID BINDING ASSAY AND SELECTION METHOD GENELABS TECH INC (US) 2001-11-29 WO claimed
WO-2001051669-A2 NUCLEIC ACID BINDING ASSAY AND SELECTION METHOD GENELABS TECHNOLOGIES, INC. (US) 2001-07-19 WO claimed
US-5919472-A DETOXIFYING ALDEHYDE-FIXED BIOLOGICAL TISSUE, SUCH AS HEART VALVE FOR IMPLANTATION BY USING A CYCLIC NONPEPTIDYL AMIDE AND/OR IMIDE FUNCTIONAL COMPOUND SUCH AS ALLANTOIN TO REMOVE EXCESS ALDEHYDE FROM THE TISSUE MEDTRONIC, INC. (US) 1999-07-06 US claimed
US-5906918-A QUANTITATING BASE MODIFICATIONS IN SAMPLE DNA BY ENDONUCLEASE DIGESTION TO DINUCLEOSIDE MONOPHOSPHATES, DEPHOSPHORYLATION, LABELING SAMPLE AND INTERNAL STANDARD DNA, ADDING COMIGRATING CARRIERS, SEPARATING SAMPLE/CARRIER FROM STANDARD/CARRIER HEALTH RESEARCH INC. (US) 1999-05-25 US claimed
US-5871992-A REPAIR OF DNA WITH ENZYME OF GLYCOSYLASE/AP LYASE ALSO FUSION PROTEINS NEW YORK UNIVERSITY (US) 1999-02-16 US claimed
US-5763180-A In vitro assay for carcinogens using phenotypic transformation of human cells VIRATEST CARCINOGEN MONITORING LTD. (CA) 1998-06-09 US claimed
EP-0796627-A2 Treatment of aldehyde-fixed tissue MEDTRONIC, INC. (US) 1997-09-24 EP claimed
WO-1997031612-A2 MAMMALIAN ENDONUCLEASE III, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF NEW YORK UNIVERSITY (US) 1997-09-04 WO claimed
US-5552285-A DIAGNOSIS AND MONITORING OF INFLAMMATORY AND AUTOIMMUNE DISEASES NEW YORK UNIVERSITY (US) 1996-09-03 US claimed
WO-1992015707-A1 IMMUNOASSAY FOR ANTIBODIES TO OXIDIZED DNA AND USES THEREOF NEW YORK UNIVERSITY (US) 1992-09-17 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577615-B2 Methods for the detection of a nucleic acid POLRMT, RNGTT, RNASE1 TSHR 2066/4885HTT 2632/4885MMP2 685/4885
US-12630851-B2 Polynucleotide modification methods PNP, NT5C3B, UNG TSHR 2677/4885HTT 2017/4885MMP2 2284/4885
US-20260098287-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS DNMT3L, ADAR, UNG TSHR 3851/4885HTT 4448/4885MMP2 413/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.