SCHEMBL480674

SCHEMBL480674

CC(C)(Cl)C(=O)c1ccc(Cc2ccc(C(=O)C(C)(C)Cl)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.54
LMNA P02545 1/20 0.47
ELANE P08246 1/20 0.44
SRD5A2 P31213 3/20 0.43
PLA2G10 O15496 1/20 0.42
PLA2G2A P14555 1/20 0.42
HDAC1 Q13547 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
OPRK1 P41145 1/20 0.39
PLK1 P53350 2/20 0.38
THRA P10827 1/20 0.38
THRB P10828 1/20 0.38
EPHX2 P34913 1/20 0.38
NR1H4 Q96RI1 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP17A1 P05093 1/20 0.37
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C19 P33261 1/20 0.37
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10946280 0.93 LMNA (0.59) KMT2ALMNAELANESRD5A2PLA2G10
SCHEMBL3682129 0.88 PLK1 (0.40) KMT2AHDAC1PLK1THRATHRB
SCHEMBL480610 0.87 LMNA (0.45) KMT2ALMNAELANEPLA2G10PLA2G2A
SCHEMBL27627345 0.86 ALDH1A1 (0.55) LMNAPLK1ALDH1A1CYP1A2CYP2C19
SCHEMBL4418249 0.85 KMT2A (0.56) KMT2ALMNAELANESRD5A2PLA2G10
SCHEMBL12535868 0.84 IDO1 (0.40) KMT2AHDAC6THRATHRBEPHX2
SCHEMBL9640323 0.83 KMT2A (0.52) KMT2ALMNAELANESRD5A2PLA2G10
SCHEMBL17338720 0.81 HDAC1 (0.41) KMT2ASRD5A2HDAC1HDAC6EPHX2
SCHEMBL153898 0.81 KMT2A (0.56) KMT2ALMNAELANESRD5A2PLA2G10
SCHEMBL4421929 0.80 ALDH1A1 (0.48) LMNAELANESRD5A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2411359-B1 NOVEL OLIGOFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2017-02-01 EP disclosed
US-8604251-B2 Oligofunctional photoinitiators BASF SE (DE) 2013-12-10 US disclosed
US-20120029107-A1 NOVEL OLIGOFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2012-02-02 US disclosed
EP-2411359-A1 NOVEL OLIGOFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2012-02-01 EP disclosed
WO-2010108862-A1 NOVEL OLIGOFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2010-09-30 WO disclosed
EP-1620475-B1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS BASF SE (DE) 2009-11-11 EP disclosed
EP-1442005-B1 NOVEL DIFUNCTIONAL PHOTOINITIATORS CIBA HOLDING INC (CH) 2009-03-18 EP disclosed
US-7462650-B2 Trifunctional photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2008-12-09 US disclosed
US-20060270748-A1 Novel trifunctional photoinitiators IGM GROUP B.V. (NL) 2006-11-30 US disclosed
US-20060209098-A1 Radiation curable ink-jet ink containing an alpha hydroxy ketone as photoinitiator FUCHS ANDRE 2006-09-21 US disclosed
US-7084183-B2 Difunctional photoinitiators CIBA SPECIALTY CHEMCIALS CORP. (US) 2006-08-01 US disclosed
EP-1620475-A1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS Ciba SC Holding AG (CH) 2006-02-01 EP disclosed
EP-1613706-A1 RADIATION CURABLE INK-JET INK CONTAINING AN ALPHA HYDROXY KETONE AS PHOTOINITIATOR Ciba SC Holding AG (CH) 2006-01-11 EP disclosed
US-20050004249-A1 Novel disfunctional photoinitiators IGM GROUP B.V. (NL) 2005-01-06 US disclosed
WO-2004099262-A1 NOVEL TRIFUNCTIONAL PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-11-18 WO disclosed
WO-2004092287-A1 RADIATION CURABLE INK-JET INK CONTAINING AN ALPHA HYDROXY KETONE AS PHOTOINITIATOR CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2004-10-28 WO disclosed
EP-1442005-A2 NOVEL DIFUNCTIONAL PHOTOINITIATORS Ciba SC Holding AG (CH) 2004-08-04 EP disclosed
WO-2003040076-A2 NOVEL DIFUNCTIONAL PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029107-A1 NOVEL OLIGOFUNCTIONAL PHOTOINITIATORS CCNA1, CCNT1, TET1 KMT2A 530/4885LMNA 4153/4885ELANE 3299/4885
US-20050004249-A1 Novel disfunctional photoinitiators ETFA, ETFB, PAH KMT2A 889/4885LMNA 2221/4885ELANE 3062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.