Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811403 | 0.82 | DGAT2 (0.47) | DGAT2CTSLCTSKCTSSALDH1A1 | |
| SCHEMBL14085366 | 0.81 | LMNA (0.51) | KDM4ELMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1812523 | 0.78 | DGAT2 (0.44) | SMN1; SMN2DGAT2CTSLCTSKCTSS | |
| SCHEMBL14110027 | 0.78 | KDM4E (0.46) | KDM4ELMNASMN1; SMN2CTSLCTSK | |
| SCHEMBL10490451 | 0.73 | KDM4E (0.48) | KDM4ELMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL2917926 | 0.73 | NPC1 (0.48) | DGAT2CTSLCTSKCTSSHDAC1 | |
| SCHEMBL1810644 | 0.72 | ALDH1A1 (0.52) | KDM4ELMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1811633 | 0.72 | PDE4D (0.47) | DGAT2LPAR1HDAC1 | |
| SCHEMBL1841568 | 0.71 | CNR2 (0.52) | KDM4ELMNASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1838271 | 0.71 | CTSL (0.48) | DGAT2CTSLCTSKCTSSLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851625-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7851625-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-14 | — | — | US | disclosed |
| US-7642352-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| US-7642352-B2 | Process for preparing 2,3-disubstituted indoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-05 | — | — | US | disclosed |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-10-22 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-7408076-B2 | 2-Bromoanaline and 2-chloroaniline compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-05 | — | — | US | disclosed |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | US | disclosed |
| EP-1727796-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-06 | — | — | EP | disclosed |
| US-7126009-B2 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2006-10-24 | — | — | US | disclosed |
| WO-2005090302-A2 | PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-29 | — | — | WO | disclosed |
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209465-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, TDO2 | KDM4E 3700/4885LMNA 4298/4885SMN1; SMN2 4754/4885 |
| US-20090264655-A1 | PROCESS FOR PREPARING 2,3-DISUBSTITUTED INDOLES | DCLK2, DCLK1, TTL | KDM4E 3298/4885LMNA 2277/4885SMN1; SMN2 4289/4885 |
| US-20060287376-A1 | Palladium catalyzed indolization of 2-bromo or chloroanilines | IDO1, IDO2, DRD3 | KDM4E 2207/4885LMNA 4264/4885SMN1; SMN2 4512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.