Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL30367664 | 1.00 | CA12 (0.40) | CA12CA1CA2CA7CA9 | |
| Potassium Ion SCHEMBL10935064 | 1.00 | CA12 (0.40) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11226776 | 0.97 | CA1 (0.40) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9302453 | 0.97 | CA1 (0.40) | CA12CA1CA2CA7CA9 | |
| Potassium Ion SCHEMBL4825140 | 0.87 | TSHR (0.43) | SMN1; SMN2TSHRMAPTALDH1A1MEN1 | |
| SCHEMBL6129097 | 0.87 | FOLH1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5904162 | 0.87 | FOLH1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL5995942 | 0.87 | FOLH1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2896479 | 0.87 | FOLH1 (0.47) | CA12CA1CA2CA7CA9 | |
| Potassium Ion SCHEMBL6129087 | 0.87 | CA12 (0.43) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230097-B2 | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2007-06-12 | — | — | US | claimed |
| US-20050113570-A1 | Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2005-05-26 | — | — | US | claimed |
| EP-0439096-A2 | Improvements in or relating to beta lactam production | BIOCHEMIE GESELLSCHAFT M.B.H. (AT) | 1991-07-31 | — | — | EP | claimed |
| EP-0019345-B1 | PROCESS FOR THE PREPARATION OF A (D-ALPHA-AMINO-(P-HYDROXYPHENYL)-ACETAMIDO) GROUP CONTAINING CEPHALOSPORANIC ACID DERIVATIVES | GIST-BROCADES N.V. (NL) | 1985-06-19 | — | — | EP | claimed |
| US-4358588-A | 7-/D-ALPHA-AMINO/P-HYDROXYPHENYL/ACETAMIDO-3- CEPHEM-4-CARBOXYLIC ACID DERIVATIVES; EFFICIENCY | GIST-BROCADES N.V. (NL) | 1982-11-09 | — | — | US | claimed |
| EP-0001133-B1 | PROCESS FOR THE PREPARATION OF 6- D-ALPHA-AMINO-(P-HYDROXYPHENYL)-ACETAMIDO PENICILLANIC ACID | GIST-BROCADES N.V. (NL) | 1982-01-20 | — | — | EP | claimed |
| EP-0019345-A1 | Process for the preparation of a (D-alpha-amino-(p-hydroxyphenyl)-acetamido) group containing cephalosporanic acid derivatives | GIST-BROCADES N.V. (NL) | 1980-11-26 | — | — | EP | claimed |
| EP-0001133-A1 | Process for the preparation of 6- D-alpha-amino-(p-hydroxyphenyl)-acetamido penicillanic acid | GIST-BROCADES N.V. (NL) | 1979-03-21 | — | — | EP | claimed |
| US-4128547-A | TERTIARY AMINE CATALYST | GIST-BROCADES N.V. (NL) | 1978-12-05 | — | — | US | claimed |
| JP-57188594-A | — | — | None | — | — | JP | disclosed |
| US-7427692-B2 | Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (US) | 2008-09-23 | — | — | US | disclosed |
| US-7355041-B2 | Intermediates in cefprozil production | SANDOZ GMBH (AU) | 2008-04-08 | — | — | US | disclosed |
| US-7230097-B2 | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2007-06-12 | — | — | US | disclosed |
| US-20060149096-A1 | Process for preparation of 7-[a-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | LUPIN LTD. (IN) | 2006-07-06 | — | — | US | disclosed |
| JP-S57188594-A | PREPARATION OF 7-(2-AMINO-2-PHENYLACETAMIDO)CEPHEM DERIVATIVE | EISAI CO LTD | 1982-11-19 | — | — | JP | disclosed |
| US-4358588-A | 7-/D-ALPHA-AMINO/P-HYDROXYPHENYL/ACETAMIDO-3- CEPHEM-4-CARBOXYLIC ACID DERIVATIVES; EFFICIENCY | GIST-BROCADES N.V. (NL) | 1982-11-09 | — | — | US | disclosed |
| EP-0001133-B1 | PROCESS FOR THE PREPARATION OF 6- D-ALPHA-AMINO-(P-HYDROXYPHENYL)-ACETAMIDO PENICILLANIC ACID | GIST-BROCADES N.V. (NL) | 1982-01-20 | — | — | EP | disclosed |
| EP-0019345-A1 | Process for the preparation of a (D-alpha-amino-(p-hydroxyphenyl)-acetamido) group containing cephalosporanic acid derivatives | GIST-BROCADES N.V. (NL) | 1980-11-26 | — | — | EP | disclosed |
| EP-0001133-A1 | Process for the preparation of 6- D-alpha-amino-(p-hydroxyphenyl)-acetamido penicillanic acid | GIST-BROCADES N.V. (NL) | 1979-03-21 | — | — | EP | disclosed |
| US-4128547-A | TERTIARY AMINE CATALYST | GIST-BROCADES N.V. (NL) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113570-A1 | Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | IGLV6-57, APC, HBZ | CA12 1149/4885CA1 1075/4885CA2 1375/4885 |
| US-20060149096-A1 | Process for preparation of 7-[a-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid | IGLV6-57, APC, IL2 | CA12 1074/4885CA1 1217/4885CA2 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.