Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 5/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816124 | 0.90 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL1455275 | 0.84 | HTR6 (0.47) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL832377 | 0.84 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL30847454 | 0.83 | SIK1 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL559567 | 0.83 | SIK1 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL482648 | 0.83 | NR1H2 (0.43) | GABRG2GABRB3GABRA5RIPK1RIPK3 | |
| SCHEMBL135567 | 0.82 | KMT2A (0.52) | KMT2AMEN1SMN1; SMN2BCHEALDH1A1 | |
| SCHEMBL34467402 | 0.82 | FGFR1 (0.51) | RIPK1RIPK3KMT2AMEN1ALDH1A1 | |
| SCHEMBL6174196 | 0.82 | HCAR3 (0.53) | RIPK1RIPK3ALDH1A1HPGD | |
| SCHEMBL16507312 | 0.81 | RIPK1 (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405299-B2 | Compounds as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405299-B2 | Compounds as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405299-B2 | Compounds as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-07-29 | — | — | US | disclosed |
| US-20060058295-A1 | Novel compounds as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058295-A1 | Novel compounds as pharmaceutical agents | TGFB1, TGFB2, TGFBR1 | GABRG2 2350/4885GABRB3 1736/4885GABRA5 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.