Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076933 | 0.89 | GLO1 (0.45) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL9076929 | 0.89 | GLO1 (0.45) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL16767840 | 0.89 | GLO1 (0.45) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL8820120 | 0.87 | SOAT1 (0.38) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL8820126 | 0.87 | SOAT1 (0.38) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL10680452 | 0.87 | SOAT1 (0.38) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL10352005 | 0.87 | ALOX15 (0.43) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL7805500 | 0.84 | ALDH1A1 (0.42) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL9648194 | 0.84 | ABCB1 (0.36) | ALDH1A1MAPTLMNAHSD17B10NPSR1 | |
| SCHEMBL8626482 | 0.84 | ABCB1 (0.36) | ALDH1A1MAPTLMNAHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| US-7384934-B2 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1546134-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | ELI LILLY AND COMPANY | 2006-04-20 | — | — | US | disclosed |
| EP-1546134-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004014895-A1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |
| EP-0728748-B1 | BENZODIAZEPINE DERIVATIVES | SHIONOGI & CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| EP-0811602-B1 | Process for the preparation of salts of the aminomalonic ester | HUELS CHEMISCHE WERKE AG (DE) | 1999-07-28 | — | — | EP | disclosed |
| US-5847197-A | Process for the preparation of aminomalonic acid ester salts | HUELS AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| US-5776929-A | GASTRIN INHIBITOR; GASTROINTESTINAL DISORDERS | SHIONOGI & CO., LTD. (JP) | 1998-07-07 | — | — | US | disclosed |
| EP-0811602-A1 | Process for the preparation of salts of the aminomalonic ester | HÜLS AKTIENGESELLSCHAFT (DE) | 1997-12-10 | — | — | EP | disclosed |
| CN-1143362-A | Novel benzodizaepine derivative | SHIONOGI & CO (JP) | 1997-02-19 | — | — | CN | disclosed |
| EP-0728748-A1 | NOVEL BENZODIAZEPINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1996-08-28 | — | — | EP | disclosed |
| EP-0257294-B1 | E/Z-ISOMERIC MIXTURES AND PURE Z-ISOMERS OF N-ALPHA-(2-CYANO-2-ALKOXYIMINOACETYL) AMINO-ACID DERIVATIVES AND LIKE PEPTIDES | BAYER AG (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0257295-B1 | (Z)-2-CYANO-2-OXIMINO-ACETYL CHLORIDES, AND PROCESS FOR THEIR PREPARATION | BAYER AG (DE) | 1990-08-29 | — | — | EP | disclosed |
| US-4904811-A | (Z)-2-cyano-2-oximino-acetyl chlorides | BAYER AKTIENGESELLSCHAFT (DE) | 1990-02-27 | — | — | US | disclosed |
| EP-0257295-A1 | (Z)-2-cyano-2-oximino-acetyl chlorides, and process for their preparation | BAYER AG (DE) | 1988-03-02 | — | — | EP | disclosed |
| EP-0257294-A1 | E/Z-isomeric mixtures and pure Z-isomers of N-alpha-(2-cyano-2-alkoxyiminoacetyl) amino-acid derivatives and like peptides | BAYER AG (DE) | 1988-03-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084643-A1 | Piperazine substituted aryl benzodiazepines | GABBR1, GABBR2, GABRA5 | ALDH1A1 215/4885MAPT 1793/4885LMNA 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.