Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYNU | Q16719 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 5/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837891 | 1.00 | KYNU (0.55) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL14567484 | 0.91 | SIRT2 (0.53) | SIRT2SIRT1ALDH1A1ALOX15CTSL | |
| SCHEMBL4407907 | 0.91 | SIRT2 (0.53) | SIRT2SIRT1ALDH1A1ALOX15CTSL | |
| SCHEMBL5189293 | 0.88 | KYNU (0.57) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL2156000 | 0.86 | KYNU (0.58) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL2155610 | 0.86 | KYNU (0.58) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL15613297 | 0.84 | CTSK (0.65) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL15757065 | 0.84 | CTSK (0.65) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL22161320 | 0.84 | CTSK (0.65) | KYNUSIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL8386880 | 0.83 | SIRT2 (0.67) | KYNUSIRT2SIRT1SIRT3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465745-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465745-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-7326719-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326719-B2 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7186827-B2 | Dipeptide synthesis | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1606258-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20050222145-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| WO-2004083182-A1 | CATHEPSIN S INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| US-20040180886-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
| US-20040180886-A1 | Cathepsin S inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180886-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | KYNU 1178/4885SIRT2 1562/4885SIRT1 1084/4885 |
| US-20050222145-A1 | Cathepsin S inhibitors | CTSS, CTSB, CTSZ | KYNU 1169/4885SIRT2 1461/4885SIRT1 1180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.