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SCHEMBL4838598

SCHEMBL4838598

CCN(C(=O)C(CCP(=O)(OCc1ccccc1)OCc1ccccc1)CC(=O)OC(C)(C)C)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 1/20 0.35
▸ CA9 Q16790 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ GPR88 Q9GZN0 2/20 0.34
▸ CETP P11597 3/20 0.34
▸ HPGD P15428 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ TP53 P04637 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ PTGES O14684 3/20 0.34
▸ ALOX5 P09917 3/20 0.34
▸ MAPT P10636 2/20 0.34
▸ FOLH1 Q04609 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ ATM Q13315 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ LTC4S Q16873 1/20 0.33
▸ SYK P43405 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4839311 0.81 FOLH1 (0.47) CA2CA9USP2CETPFOLH1
SCHEMBL4841242 0.80 ALDH1A1 (0.38) CA2CA9GPR88HPGDTP53
SCHEMBL4838594 0.80 CA2 (0.45) CA2CA9USP2HPGDMEN1
SCHEMBL4841055 0.78 SMN1; SMN2 (0.41) USP2GPR88SMN1; SMN2MAPTRAB9A
SCHEMBL4838569 0.76 KIF11 (0.36) GPR88PTGESALOX5ATMTDP1
SCHEMBL4840415 0.74 MLYCD (0.41) GPR88HPGDSMN1; SMN2PTGESALOX5
SCHEMBL4831400 0.74 CYP3A4 (0.38) CA2CA9GPR88PTGESALOX5
SCHEMBL4835854 0.73 ALDH1A1 (0.39) GPR88HPGDMAPTFOLH1ALDH1A1
SCHEMBL4840808 0.70 CA2 (0.35) CA2CA9USP2GPR88L3MBTL1
SCHEMBL4831152 0.70 PPARA (0.39) USP2FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365091-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2008-04-29 — — US disclosed
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2006-12-21 — — US disclosed
US-7105539-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-09-12 — — US disclosed
EP-1572645-A2 DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX Enobia Pharma Inc. (CA) 2005-09-14 — — EP disclosed
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex BIOMEP INC. 2004-09-23 — — US disclosed
WO-2004050620-A2 DERIVATIVES OF SUCCINIC AND GLUTARIC ACIDS AND ANALOGS THEREOF USEFUL AS INHIBITORS OF PHEX ENOBIA PHARMA (CA) 2004-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX GLS, SUCNR1, PGD CA2 333/4885CA9 776/4885USP2 2926/4885
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, PGD CA2 344/4885CA9 841/4885USP2 3011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.