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Sugi Predict / Compounds / SCHEMBL4841242

SCHEMBL4841242

SCHEMBL4841242

CCN(C(=O)C(CC(=O)O)CC(=O)OC(C)(C)C)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.38
▸ GLA P06280 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ GPR88 Q9GZN0 4/20 0.38
▸ MMP12 P39900 2/20 0.36
▸ PTGES O14684 1/20 0.35
▸ ALOX5 P09917 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ CA9 Q16790 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ MLYCD O95822 1/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ FFAR1 O14842 1/20 0.34
▸ CTSS P25774 1/20 0.34
▸ CTSK P43235 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4841055 0.91 SMN1; SMN2 (0.41) ALDH1A1GLATSHRGPR88MAPT
SCHEMBL6252531 0.88 ALDH1A1 (0.49) ALDH1A1GLATSHRGPR88MMP12
SCHEMBL4838569 0.82 KIF11 (0.36) ALDH1A1GLATSHRGPR88PTGES
SCHEMBL4838598 0.80 CA2 (0.35) ALDH1A1GPR88PTGESALOX5MAPT
SCHEMBL4840370 0.80 MMP9 (0.43) ALDH1A1GLATSHR
SCHEMBL4840808 0.80 CA2 (0.35) ALDH1A1GLATSHRGPR88CA2
SCHEMBL4840333 0.80 CA2 (0.35) ALDH1A1GPR88MAPTCA2CA9
SCHEMBL4831400 0.80 CYP3A4 (0.38) GPR88PTGESALOX5CA2CA9
SCHEMBL4835195 0.79 FOLH1 (0.41) ALDH1A1GLATSHRGPR88MMP12
SCHEMBL4840415 0.78 MLYCD (0.41) ALDH1A1GPR88MMP12PTGESALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365091-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2008-04-29 — — US disclosed
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2006-12-21 — — US disclosed
US-7105539-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-09-12 — — US disclosed
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-06-22 — — US disclosed
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex BIOMEP INC. 2004-09-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX GLS, SUCNR1, PGD ALDH1A1 1377/4885GLA 118/4885TSHR 4496/4885
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, PGD ALDH1A1 1271/4885GLA 135/4885TSHR 4547/4885
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, GCDH ALDH1A1 1091/4885GLA 127/4885TSHR 4541/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.