Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 13/20 | 0.48 |
| ▸ | MMP8 | P22894 | 13/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.48 |
| ▸ | MMP3 | P08254 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 12/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.45 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | MMP15 | P51511 | 1/20 | 0.45 |
| ▸ | MMP16 | P51512 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.45 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.45 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557419 | 0.83 | KMT2A (0.42) | MMP9MMP8MMP1MMP2MEN1 | |
| SCHEMBL4835871 | 0.81 | SIGMAR1 (0.48) | MMP9MMP8MMP2LTA4HALDH1A1 | |
| SCHEMBL6394938 | 0.76 | ALDH1A1 (0.56) | ADAM17MEN1NPC1MITFALDH1A1 | |
| SCHEMBL4838038 | 0.75 | USP2 (0.39) | MMP9MMP8MMP2MEN1NPC1 | |
| SCHEMBL4840370 | 0.75 | MMP9 (0.43) | MMP9MMP8MMP1MMP3MMP2 | |
| SCHEMBL27474102 | 0.73 | LMNA (0.58) | MEN1NPC1MITFALDH1A1RAB9A | |
| SCHEMBL4840553 | 0.72 | MEN1 (0.60) | MMP9MMP8MMP1MMP2LTA4H | |
| SCHEMBL26978217 | 0.72 | ALDH1A1 (0.51) | MEN1NPC1MITFALDH1A1RAB9A | |
| SCHEMBL7888701 | 0.70 | ALDH1A1 (0.52) | MEN1NPC1MITFALDH1A1RAB9A | |
| SCHEMBL7893567 | 0.70 | MEN1 (0.67) | MEN1NPC1MITFALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365091-B2 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | ENOBIA PHARMA (CA) | 2008-04-29 | — | — | US | disclosed |
| US-20060287280-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | ENOBIA PHARMA (CA) | 2006-12-21 | — | — | US | disclosed |
| US-7105539-B2 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | ENOBIA PHARMA (CA) | 2006-09-12 | — | — | US | disclosed |
| US-20060135480-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | ENOBIA PHARMA (CA) | 2006-06-22 | — | — | US | disclosed |
| US-20040186301-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | BIOMEP INC. | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287280-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX | GLS, SUCNR1, PGD | MMP9 3110/4885MMP8 4356/4885MMP1 3031/4885 |
| US-20040186301-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | GLS, SUCNR1, PGD | MMP9 3196/4885MMP8 4395/4885MMP1 2905/4885 |
| US-20060135480-A1 | Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex | GLS, SUCNR1, GCDH | MMP9 3234/4885MMP8 4405/4885MMP1 3004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.