Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TTR | P02766 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322531 | 0.89 | GPR35 (1.00) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL28817836 | 0.87 | GPR35 (0.95) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL1943304 | 0.84 | GPR35 (0.74) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL11113072 | 0.83 | GPR35 (0.67) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL13681604 | 0.83 | GPR35 (0.80) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL10749719 | 0.83 | GPR35 (0.80) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL11095256 | 0.80 | GPR35 (0.62) | GPR35ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL11396860 | 0.80 | GPR35 (0.62) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL3360011 | 0.80 | GPR35 (0.74) | GPR35ALDH1A1TTRMEN1MAPT | |
| SCHEMBL8024018 | 0.80 | GPR35 (0.74) | GPR35ALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558842-B | Pyrimidine derivative anaplastic lymphoma kinase inhibitor | 山东轩竹医药科技有限公司 | 2021-06-04 | — | — | CN | disclosed |
| CN-107108586-B | Polycyclic anaplastic lymphoma kinase inhibitors | 山东轩竹医药科技有限公司 | 2020-07-10 | — | — | CN | disclosed |
| EP-3202765-B1 | POLYCYCLIC ANAPLASTIC LYMPHOMA KINASE INHIBITOR | HAINAN XUANZHU PHARMA CO LTD (CN) | 2020-03-25 | — | — | EP | disclosed |
| CN-106146478-B | Triazine derivatives species anaplastic lymphoma kinase inhibitor | 海南轩竹医药科技有限公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-108558842-A | Pyrimidine derivates species anaplastic lymphoma kinase inhibitor | 山东轩竹医药科技有限公司 | 2018-09-21 | — | — | CN | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | Xuanzhu Pharma Co., Ltd. (CN) | 2018-07-03 | — | — | US | disclosed |
| CN-104892585-B | Pyrimidine derivative anaplastic lymphoma kinase inhibitor | 山东轩竹医药科技有限公司 | 2018-07-03 | — | — | CN | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | Xuanzhu Biopharmaceutical Co., Ltd. (CN) | 2018-03-29 | — | — | US | disclosed |
| US-20130066044-A1 | POLYCARBONATE POLYOL COMPOSITIONS AND METHODS | NOVOMER, INC. (US) | 2013-03-14 | — | — | US | disclosed |
| US-8247520-B2 | Polycarbonate polyol compositions and methods | NOVOMER, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20110230580-A1 | POLYCARBONATE POLYOL COMPOSITIONS AND METHODS | Novomer, Inc (US) | 2011-09-22 | — | — | US | disclosed |
| US-7371866-B2 | Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2008-05-13 | — | — | US | disclosed |
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC. (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1390336-A1 | METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2004-02-25 | — | — | EP | disclosed |
| US-20030216577-A1 | Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis | DSM FINE CHEMICALS AUSTRIA NFG GMBH & COKG (AT) | 2003-11-20 | — | — | US | disclosed |
| EP-1362840-A1 | Process for the preparation of aromatic and heteroaromatic carboxylic acids via catalytic ozonolysis | DSM Fine Chemicals Austria Nfg GmbH & Co KG (AT) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002096849-A1 | METHOD FOR PRODUCING AROMATIC ALDEHYDES AND KETONES BY THE CATALYTIC OXIDATION OF ALKYL-AROMATIC COMPOUNDS | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086745-A9 | POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE | IKBKE, DCK, CHUK | GPR35 2695/4885ALDH1A1 1865/4885TTR 2208/4885 |
| US-20070276011-A1 | Plasminogen Activator Inhibitor-1 Inhibitor | SERPINE1, SERPINC1, SERPINB1 | GPR35 3319/4885ALDH1A1 1861/4885TTR 1154/4885 |
| US-20110230580-A1 | POLYCARBONATE POLYOL COMPOSITIONS AND METHODS | PARG, PUF60, PICALM | GPR35 2808/4885ALDH1A1 3934/4885TTR 4716/4885 |
| US-10011592-B2 | Polycyclic inhibitor of anaplastic lymphoma kinase | IKBKE, DCK, CHUK | GPR35 2695/4885ALDH1A1 1865/4885TTR 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.