Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PMM2 | O15305 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 4/20 | 0.38 |
| ▸ | PRKCB | P05771 | 4/20 | 0.38 |
| ▸ | PRKCA | P17252 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355781 | 0.90 | HSP90AA1 (0.46) | HSP90AA1HTR7TLR9MGLL | |
| SCHEMBL6345973 | 0.87 | MGLL (0.45) | HSP90AA1ALDH1A1SMN1; SMN2TLR9MGLL | |
| SCHEMBL6345530 | 0.82 | MGLL (0.50) | HSP90AA1ALDH1A1POLBTLR9MGLL | |
| SCHEMBL6354137 | 0.78 | ALDH1A1 (0.41) | HSP90AA1HTR7ALDH1A1RAB9APMM2 | |
| SCHEMBL6348067 | 0.75 | TLR9 (0.40) | ALDH1A1TLR9MGLLFAAH | |
| SCHEMBL6344199 | 0.75 | TLR9 (0.40) | ALDH1A1RAB9ANPC1TLR9MGLL | |
| SCHEMBL4845035 | 0.75 | PRKCB (0.45) | HTR7ALDH1A1TLR9GAAPRKCG | |
| SCHEMBL29510752 | 0.75 | HSP90AA1 (1.00) | HSP90AA1ALDH1A1MGLLFAAH | |
| SCHEMBL2146237 | 0.75 | HSP90AA1 (1.00) | HSP90AA1ALDH1A1MGLLFAAH | |
| SCHEMBL29030268 | 0.74 | HTR7 (0.42) | HSP90AA1HTR7ALDH1A1RAB9APMM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329657-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7304060-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ZHANG HAN-CHENG (US) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004202-A1 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | MAP2K2, MAP3K20, MAP2K3 | HSP90AA1 1339/4885HTR7 3837/4885ALDH1A1 3369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.