Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 11/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6344247 | 0.83 | MGLL (0.44) | TLR9MGLLMEN1NPC1RAB9A | |
| SCHEMBL6345530 | 0.82 | MGLL (0.50) | TLR9MGLLFAAHKDM4EALDH1A1 | |
| SCHEMBL4845035 | 0.75 | PRKCB (0.45) | TLR9MGLLALDH1A1 | |
| SCHEMBL6348067 | 0.75 | TLR9 (0.40) | TLR9MGLLFAAHCHRM1KDM4E | |
| SCHEMBL4849912 | 0.75 | HSP90AA1 (0.58) | TLR9MGLLNPC1RAB9AFAAH | |
| SCHEMBL6355781 | 0.71 | HSP90AA1 (0.46) | TLR9MGLLCHRM1 | |
| SCHEMBL28090496 | 0.71 | MGLL (0.54) | MGLLFAAHALDH1A1 | |
| SCHEMBL6345973 | 0.69 | MGLL (0.45) | TLR9MGLLMEN1KMT2AKDM4E | |
| SCHEMBL5688433 | 0.69 | TLR9 (0.50) | TLR9MGLLKMT2AFAAHALDH1A1 | |
| SCHEMBL4847504 | 0.69 | PRKCG (0.41) | TLR9MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |