Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849912 | 0.87 | HSP90AA1 (0.58) | MGLLHSP90AA1ALDH1A1TLR9SMN1; SMN2 | |
| SCHEMBL6355781 | 0.83 | HSP90AA1 (0.46) | MGLLHSP90AA1TLR9CYP1A2NPSR1 | |
| SCHEMBL6345530 | 0.76 | MGLL (0.50) | MGLLHSP90AA1KDM4EALDH1A1HTT | |
| SCHEMBL6344199 | 0.69 | TLR9 (0.40) | MGLLKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4845035 | 0.69 | PRKCB (0.45) | MGLLALDH1A1MAPTHTTHSD17B10 | |
| SCHEMBL6348067 | 0.69 | TLR9 (0.40) | MGLLKDM4EALDH1A1TLR9 | |
| SCHEMBL6344247 | 0.68 | MGLL (0.44) | MGLLHSP90AA1ALDH1A1HTTMEN1 | |
| SCHEMBL6354137 | 0.67 | ALDH1A1 (0.41) | HSP90AA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6404071 | 0.67 | CYP1A2 (0.62) | MGLLHSP90AA1KDM4EALDH1A1HTT | |
| SCHEMBL5688433 | 0.67 | TLR9 (0.50) | MGLLALDH1A1MAPTKMT2ATLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849643-B2 | Indazolyl-substituted pyrroline compounds as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-02-01 | — | — | US | disclosed |