Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.61 |
| ▸ | AR | P10275 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12339907 | 0.82 | ESR1 (0.57) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL4853969 | 0.81 | TSHR (0.48) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL18604566 | 0.80 | TRPA1 (0.46) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL3313456 | 0.77 | ALDH1A1 (0.42) | ESR1ESR2ARTDP1KDM4E | |
| SCHEMBL13318430 | 0.76 | ESR1 (0.36) | ESR1ESR2ARTP53TDP1 | |
| SCHEMBL3824007 | 0.75 | ALDH1A1 (0.40) | ESR1ESR2ARTDP1KDM4E | |
| SCHEMBL13086248 | 0.74 | ALDH1A1 (0.52) | ESR1ESR2ARTDP1PDE10A | |
| SCHEMBL1920935 | 0.74 | ACHE (0.39) | ESR1ESR2ARKDM4ECYP3A4 | |
| SCHEMBL18234154 | 0.73 | ESR1 (0.33) | ESR1ESR2AR | |
| SCHEMBL17746494 | 0.73 | ESR1 (0.34) | ESR1ESR2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118184833-A | Phenolic amine type internal electron donor composition for ethylene polymerization catalyst and preparation method thereof | 中国石油天然气股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| US-7737291-B2 | 2,4,6,8-tetramethylcyclotetrasiloxane and stabilizer used as a material for thin film formation by chemical vapor deposition, or atomic layer deposition | ADEKA CORPORATION (JP) | 2010-06-15 | — | — | US | disclosed |
| US-20080261918-A1 | Silicon Compounds and Their Use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-23 | — | — | US | disclosed |
| US-7407649-B2 | Compounds having a benzene ring substituted with 1 or 2 trialkylsilyl(alkyl) groups and at least 2 additional aryl or heteroaryl rings: 5-[2-methyl-5-(trimethylsilyl)phenoxy]-N-(2,6-dimethoxyphenyl)furan-2-carboxamide; Gonadotropin-Releasing Hormone antagonists; anticancer agents | PARADIGM THERAPEUTICS LTD (GB) | 2008-08-05 | — | — | US | disclosed |
| US-7407649-B2 | Compounds having a benzene ring substituted with 1 or 2 trialkylsilyl(alkyl) groups and at least 2 additional aryl or heteroaryl rings: 5-[2-methyl-5-(trimethylsilyl)phenoxy]-N-(2,6-dimethoxyphenyl)furan-2-carboxamide; Gonadotropin-Releasing Hormone antagonists; anticancer agents | PARADIGM THERAPEUTICS LTD (GB) | 2008-08-05 | — | — | US | disclosed |
| US-20070232821-A1 | Composition Containing Siloxane Compound and Phenol Compound | ADEKA CORPORATION (JP) | 2007-10-04 | — | — | US | disclosed |
| EP-1644385-B1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2007-08-29 | — | — | EP | disclosed |
| EP-1644385-B1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2007-08-29 | — | — | EP | disclosed |
| US-20070110708-A1 | Silicon compounds and their use | PARADIGM THERAPEUTICS LTD (GB) | 2007-05-17 | — | — | US | disclosed |
| US-20070110708-A1 | Silicon compounds and their use | PARADIGM THERAPEUTICS LTD (GB) | 2007-05-17 | — | — | US | disclosed |
| CN-1823076-A | Silicon compounds and their use | PARADIGM THERAPEUTICS LTD (GB) | 2006-08-23 | — | — | CN | disclosed |
| EP-1644385-A1 | SILICON COMPOUNDS AND THEIR USE | Paradigm Therapeutics Limited (GB) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005442-A1 | SILICON COMPOUNDS AND THEIR USE | PARADIGM THERAPEUTICS LTD. (GB) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070110708-A1 | Silicon compounds and their use | SOST, SMAD3, SMAD2 | ESR1 533/4885ESR2 476/4885AR 1957/4885 |
| US-20070232821-A1 | Composition Containing Siloxane Compound and Phenol Compound | H1-0, CYP2S1, H1-4 | ESR1 46/4885ESR2 283/4885AR 110/4885 |
| US-20080261918-A1 | Silicon Compounds and Their Use | SOST, SIK2, SCLY | ESR1 492/4885ESR2 231/4885AR 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.