Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1003364 | 0.98 | AVPR1A (0.43) | AVPR1ACHRNB2CHRNA4CCNCCDK8 | |
| SCHEMBL13668210 | 0.87 | CHRNB2 (0.43) | AVPR1ACHRNB2CHRNA4CCNCCDK8 | |
| SCHEMBL25307002 | 0.83 | AVPR1A (0.40) | AVPR1ACHRNB2CHRNA4 | |
| SCHEMBL30527669 | 0.83 | AVPR1A (0.40) | AVPR1ACHRNB2CHRNA4 | |
| SCHEMBL30447448 | 0.83 | AVPR1A (0.42) | AVPR1ACCNCCDK8HASPINCDK19 | |
| SCHEMBL31059162 | 0.82 | AVPR1A (0.39) | AVPR1ACHRNB2CHRNA4 | |
| SCHEMBL23304985 | 0.82 | AVPR1A (0.39) | AVPR1ACHRNB2CHRNA4 | |
| SCHEMBL24204169 | 0.79 | AVPR1A (0.45) | AVPR1A | |
| SCHEMBL14996486 | 0.79 | AVPR1A (0.50) | AVPR1AOPRD1 | |
| SCHEMBL30447418 | 0.79 | AVPR1A (0.45) | AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200352931-A1 | OXALAMIDES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Phenex Discovery Verwaltungs-GmbH (DE) | 2020-11-12 | — | — | US | disclosed |
| WO-2019115586-A1 | OXALAMIDES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | Phenex Discovery Verwaltungs-GmbH (DE) | 2019-06-20 | — | — | WO | disclosed |
| EP-3218381-B1 | SPIRO-THIAZOLONES | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-10092551-B2 | Spiro-thiazolones | HOFFMANN-LAROCHE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-3218381-A1 | SPIRO-THIAZOLONES | F. Hoffmann-La Roche AG (CH) | 2017-09-20 | — | — | EP | disclosed |
| US-20170246153-A1 | SPIRO-THIAZOLONES | HOFFMANN-LA ROCHE INC. (US) | 2017-08-31 | — | — | US | disclosed |
| WO-2016075181-A1 | SPIRO-THIAZOLONES | F. HOFFMANN-LA ROCHE AG (CH) | 2016-05-19 | — | — | WO | disclosed |
| US-20150266839-A1 | CYCLIC AMIDE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-09-24 | — | — | US | disclosed |
| US-20150225392-A1 | CYCLIC AMIDE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-08-13 | — | — | US | disclosed |
| US-9072758-B2 | Cyclic amide derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-07-07 | — | — | US | disclosed |
| US-20080281103-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-11-13 | — | — | US | disclosed |
| US-20080281103-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-11-13 | — | — | US | disclosed |
| WO-2008080844-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008080844-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | WO | disclosed |
| US-20080161333-A1 | AZASPIRO DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161333-A1 | AZASPIRO DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161333-A1 | AZASPIRO DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161332-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | US | disclosed |
| US-20080161332-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | US | disclosed |
| US-20080161332-A1 | AZASPIRO DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352931-A1 | OXALAMIDES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | AVPR1A 2904/4885CHRNB2 1715/4885CHRNA4 1770/4885 |
| US-20150266839-A1 | CYCLIC AMIDE DERIVATIVE | GPR119, NR0B1, NR4A1 | AVPR1A 472/4885CHRNB2 432/4885CHRNA4 186/4885 |
| US-10092551-B2 | Spiro-thiazolones | AVPR1A, AVPR2, AVPR1B | AVPR1A 1/4885CHRNB2 1987/4885CHRNA4 220/4885 |
| US-20150225392-A1 | CYCLIC AMIDE DERIVATIVE | GPR119, NR0B1, NR2C2 | AVPR1A 301/4885CHRNB2 517/4885CHRNA4 425/4885 |
| US-20080281103-A1 | AZASPIRO DERIVATIVES | AVPR1A, HTR5A, HTR1A | AVPR1A 1/4885CHRNB2 226/4885CHRNA4 48/4885 |
| US-20080161332-A1 | AZASPIRO DERIVATIVES | AVPR1A, HTR5A, HTR1A | AVPR1A 1/4885CHRNB2 226/4885CHRNA4 48/4885 |
| US-20080161333-A1 | AZASPIRO DERIVATIVES | AVPR1A, HTR5A, HTR1A | AVPR1A 1/4885CHRNB2 226/4885CHRNA4 48/4885 |
| US-20170246153-A1 | SPIRO-THIAZOLONES | AVPR1A, AVPR2, AVPR1B | AVPR1A 1/4885CHRNB2 1987/4885CHRNA4 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.