Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | GUSB | P08236 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28814893 | 0.88 | BCHE (0.75) | BCHEGUSBMAPTLMNAMAOB | |
| SCHEMBL675698 | 0.88 | BCHE (0.75) | BCHEGUSBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8101054 | 0.88 | BCHE (0.75) | BCHEGUSBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL23956015 | 0.86 | LMNA (0.61) | BCHEGUSBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL11528927 | 0.84 | GPR52 (0.61) | MAPTKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL11528932 | 0.84 | GPR52 (0.61) | MAPTKDM4ESMN1; SMN2LMNAHTT | |
| SCHEMBL23830003 | 0.84 | CHRNA7 (0.60) | MAPTKDM4ESMN1; SMN2MEN1POLB | |
| SCHEMBL15631497 | 0.84 | ABCG2 (0.68) | BCHEMAPTKDM4EMEN1POLB | |
| SCHEMBL23830004 | 0.84 | CHRNA7 (0.60) | MAPTKDM4ESMN1; SMN2MEN1POLB | |
| SCHEMBL25289436 | 0.81 | NFE2L2 (0.71) | BCHEGUSBMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118894756-A | Deoxidization and reduction method for alpha, beta unsaturated ketone | 温州医科大学 | 2024-11-05 | — | — | CN | disclosed |
| WO-2023177194-A1 | NOVEL DIMETHYLCHALCONE DERIVATIVES | 중앙대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177191-A1 | COMPOSITION FOR PREVENTING OR TREATING FIBROTIC DISEASES, COMPRISING DIMETHYLCHALCONE DERIVATIVE AS ACTIVE INGREDIENT | 서울대학교 산학협력단 | 2023-09-21 | — | — | WO | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) | 2023-08-10 | — | — | US | disclosed |
| WO-2022060169-A4 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | 서울대학교 산학협력단 | 2022-05-12 | — | — | WO | disclosed |
| US-7432303-B2 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | Bowen, J. Phillip (US) | 2008-10-07 | — | — | US | disclosed |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248665-A1 | COMPOSITION COMPRISING DIMETHYLCHALCONE DERIVATIVE FOR PREVENTION OR TREATMENT OF METABOLIC DISEASE | LIPC, PC, CYP27A1 | BCHE 612/4885GUSB 2657/4885MAPT 1563/4885 |
| US-20050148599-A1 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states | FLT1, VEGFA, FLT4 | BCHE 4276/4885GUSB 2239/4885MAPT 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.